CP-108

Amyotrophic lateral sclerosis
CP-108

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease, with an annual incidence of 1 to 2 new cases per 100,000 people. It damages motor neurons in the brain and spinal cord, leading to muscle weakness, paralysis, and respiratory failure. Symptoms typically start with muscle twitching, cramps, or limb weakness and progress to difficulty speaking, swallowing, and breathing. Most ALS cases involve abnormal TDP-43, which plays a crucial role in RNA processing and motor neuron degeneration. About 90% of ALS patients die within 3 to 5 years of diagnosis, usually from respiratory failure. While some treatments may modestly slow progression, there is no cure, and most therapies focus on managing symptoms.